Since Maxim asked in one of his more modern comments regarding the usefulness or downsides of forskolin for women, I dediced to dedicate this Sunday (finally again?) to answering an end user question and am planning to briefly summarize some older as well as the few novel findings on forskolin I am aware about.
For those of you who find that boring: Don’t blame Maxim alone, another reason why with this decision was i have experienced discussions on forskolin resurface elsewhere around the Internet. By the way, I write re-surfaced, because forskolin has once been hailed as being a testbooster and fat loss adjuvant, but since the prices increased and people arrived with faked or low-quality goods that failed to yield results, the marketplace collapsed.
As usually there may be more than a single response to this inquiry. Probably the most simple general ones are probably (a) it is a white to white with yellow cast powder, or (b) a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory and adenylate cyclase activating properties. Moreover, forskolin is able to activate the adenylate cyclase and so increase the intracellular cyclic AMP levels generally in most tissues and cells. And hat it’s called forskolin, since it is produced from the Indiant plan Coleus forskohlii might be something 99% of you knew already.
The reason why I guess that Maxim got interested in it, is it is normally utilized in cell studies to increase the amount of cyclic AMP (cAMP; cf. Alasbahi. 2012) and did a pretty impressive job from the recently discussed PGC-1a study. On the flip side, it did also raise the expression of your aromatase enzyme within the Yang study mentioned from the “Natural Sildenafil & Testosterone Alternative” post where Maxim replied using the initially mentioned comment.
“Wait, wasn’t it said to be a testbooster and now it also inhibits myostatin and increases estrogen? What does this stuff not do?” – Well, forskolin is, above all, a cAMP modulator
Forskolins chemical structure. Sometimes it’s also referred to as Colforsin; 7-beta-acetoxy-8, 13-epoxy-1-alpha, 6-beta, 9-alpha-trihydroxylabd-14-en-11-one; or Coleonol (img. from Sigma-Aldrich’s product database)
I know that sounds confusing, but in essence forskolin does outright increasing cAMP levels in almost all kinds of cells. cAMP a breakdown product of ATP (=> cAMP => AMP) subsequently is one of the molecules which exert most their effects as intracellular signal transducer. Because, it is active in the activation of protein kinases and regulates the impact of adrenaline and glucagon. Furthermore, it modulates the calcium channels and contributes to growth hormone release; unfortunately, cAMP has additionally been implicated from the proliferation of not so beneficial cell growth aka cancer. Exactly the same ion-flux mediation has been implicated from the etiology of ADHD, as well.
In a 2005 study (Godard. 2005), which caused a good stir from the health and fitness community in those days, Godard et al. observed profound beneficial results of testosterone and the entire body composition (cf. figure 1) right after the ingestion of 2x250mg of the 10% standardized forskolin (Forslean).
Now, the unfortunate truth is that the15 subjects (average age, BMI, and the entire body fat percent were 24.4 /- 5.9 years, 32.5 /- 4.1 kg/m2 , and 35.2 /- 8.3%) who had been randomized to the active arm of your study, as well as the 15 participants inside the placebo arm (28.7 /- 8.6 years, 32.6 /- 3.8 kg/m2 , and 35. /- 7.3%) were non-active devdpky98 overweight/obese (BMI 26 kg/m2 or even more) individuals. Add the funding by Sabinsa (Forslean producer) on the equation and choose yourself how relevant you think the results will probably be for you personally…
In a number of in-vitro studies, forskolin supplements has been utilized as a positive control to compare and contrast the effects of other compounds about the testosterone release in leydig cells. Lin et al. as an example used it in 2001 as a comparison for lactate and discovered a ~3x increase in testosterone release in incubated leydig cells (Lin. 2001). A comparable study by Yu et al. revealed that incorporating green tea catechins result in an extra stimulation of forskolin induced testosterone production in cell cultures (Yu. 2010).
As part of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, retinol and, obviously, forskolin it has shown some promise like a topical anti-cellulite and toning agent (Roure. 2011). The clinical study was however financed by Johnson & Johnson and i also am unclear how much of the effects were actually caused by forskolin (the placebo was really a basic gel with similar texture containing mainly water, gelifying and preservative systems). So use the data in figure 2 with a grain of salt, ladies – I bet 12 weeks with this product will not be exactly inexpensive.
The administration of forskolin along with rutin (the glycoside between your flavonol quercetin as well as the disaccharide rutinose), vitamin B1 & B2 within a 2010 study by Pescosolido et. al. cause a significant decrease in intra-ocular pressure in 15 glaucoma patients after 40 days (Pescosolido. 2010). Similar effects were observed in a 2012 study for forskolin and rutin alone.
An in-vitro study by Cristobal et al. provides first evidence to the ability of forskolin to revive PPA2 in acute myeloid leukemia. That could make it the potential candidate for the treatment of this sort of cancer, but to my knowledge there may be at the time of yet not actually a rodent study that would support these in-vitro results. Moreover, previous research has suggested that Forskolin might even favor the proliferation of other kinds of leukemia (Kobayashi. 1994)
In view of the reality that the previously mentioned study by Godard will be the only human study is simply backed up by in-vitro data from rodent studies (Litosch. 1982, cf. figure 3), the fat loss benefits are as Jeukendrup et al. explain inside their 2011 report on purported fat burners…
When you add to this the host of wanted and unwanted, known and unknown unwanted effects that occur in reply to the coleus foskohlii induced cytochrome P450 modulation (e.g. the mice within the aforementioned study by Virgona lost some visceral fat, nevertheless the costs were increased fat deposition from the liver and elevated transaminase levels).
With all the questionable “fat loss” benefits (remember stress is another powerful lypolitic and the issue is not to get the fat out of the cell, but alternatively to get rid of it), and the almost non-existant human data about the purported testosterone boosting effects, this needs to be reason enough not to buy a lot more than one bottle for any test-run. And after that I highly suggest to perform some lab work to ascertain if whatever good or bad you believe you are feeling is surely an actual boost in T (check T-levels) or hepatic unwanted effects (check ALT, AST & ALP).
Note (update in response to comments): With regards to the hepatoxicity is concerned the suggested dosage of forskolin most supplements come with could be greater than the medium dose inside the study by Virgona, but remains to be probably “liver save” if you double dose on that, you happen to be however landing within the no-man’s land (=not tested for) gray zone involving the medium dosage and the “danger zone” of ~49mg/kg each day (human dose equivalent) which had been tested inside the study. Don’t freak out, in the event you did that before, the amount return to normal afterwards and temporarily elevated ALT AST or ALP levels do not really signify your liver is whacked forever.